Skip to main content
. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: CNS Oncol. 2013 Mar;2(2):171–179. doi: 10.2217/cns.12.46

Figure 2. Tumor homogenization by dendritic cell vaccination.

Figure 2

(A) Similarity of overall gene expression in paired pre- and post-vaccine glioblastoma multiforme samples from the same six patients shows significantly increased homogeneity after vaccination (Pearson’s coefficients for all pairwise sample combinations and all transcripts on Affymetrix [CA, USA] HGG-133+2 chips is shown; the p-value between pre- and post-vaccine samples was calculated by 2-sided T-test). (B) Sequencing of IDH1-mutated tumor samples revealed an increase in IDH1-mutated signal (CGT→CAT at codon 132) within tumor tissue after vaccination.