Skip to main content
. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: CNS Oncol. 2013 Mar;2(2):171–179. doi: 10.2217/cns.12.46

Figure 3. Changes in glioblastoma multiforme molecular subtype according to dendritic cell vaccination.

Figure 3

After dendritic cell vaccination, patient tumor gene expression profiles shift from MES, toward PRO and PN subclasses. The MES subclass is characterized by upregulation of genes controlling migration and motility; the PRO subclass is characterized by upregulation of DNA replication and cell cycle regulatory genes; and the PN subclass is by characterized by the upregulation of genes involved in neural development [34]. Similar changes in gene expression were not observed in patients receiving chemotherapy.

MES: Mesenchymal; PN: Proneural; PRO: Proliferative.