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Progranulin haploinsufficiency impairs fear conditioning. 12-month-old mice from a mixed (A, N = 54–59 mice per genotype) or congenic C57BL/6 (B, N = 17–19 mice per genotype) background were tested for cued fear conditioning one day after training. A significant effect of progranulin deficiency was observed in mice on both backgrounds (ANOVA, p < 0.01). Both Grn+/− and Grn−/− mice spent a significantly less time immobile than Grn+/+ mice (** p <0.001, *** p <0.0001 by post-hoc test).
