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. Author manuscript; available in PMC: 2006 Jan 27.
Published in final edited form as: J Neurosci. 2005 Jun 29;25(26):6199–6207. doi: 10.1523/JNEUROSCI.1148-05.2005

Figure 5.

Figure 5.

Effects of WIN55212-2 on IPSCs are calcium dependent. A, WIN55212-2 suppression of IPSCs in the present of TTX (1μM). A–C, Under this condition, activation of CB1 receptors by WIN55212-2 decreased the frequency and amplitude of action potential-independent IPSCs. GABAergic events were collected in 5 pA bins for plotting histograms of event amplitude, as shown in B and C. Note that the bin size in A has been increased to 20 s. E, [Ca2+]o (0.1 mM) plus TTX prevented WIN55212-2 effects on IPSCs. D, E, Histograms of GABAergic event amplitudes from a representative experiment; bin size is 2 pA. Recordings (3 min) were collected for [Ca2+]o = 2 mM and 10 min recordings for [Ca2+]o = 0.1 mM. F, GABAergic sIPSC frequency and amplitude were not altered by WIN55212-2 in the presence of 0.1 mM [Ca2+]o plus TTX. [K +]o was 5 mM in all tests.