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. Author manuscript; available in PMC: 2013 Nov 22.
Published in final edited form as: J Neurosci. 2013 Mar 27;33(13):10.1523/JNEUROSCI.3342-12.2013. doi: 10.1523/JNEUROSCI.3342-12.2013

Figure 7.

Figure 7

Characterization of structural changes following PNL of sciatic nerves in scLRP1−/− mice. (A–D) Transverse semi-thin plastic sections of PNL-injured sciatic nerves isolated 20 days after injury and stained with methylene blue/Azure II. Asterisks in panels A and B identify areas shown in panels C and D at higher magnifcation. Arrowheads in panel C identify myelinated axons. Arrowheads in panel D show degenerated nerve fibers. (E, F) TEM analysis of PNL-injured sciatic nerves isolated 20 days after injury. The images shown are representative of studies conducted with 3–4 mice/group. (G) Immunoblot analysis of MBP levels in PNL-injured nerves isolated 20 days after injury. Each lane represents an individual mouse. (H) Quantification of immunoblots by densitometry (*p<0.05; n=4/group).