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. Author manuscript; available in PMC: 2014 Apr 11.
Published in final edited form as: ACS Med Chem Lett. 2013 Mar 25;4(4):397–401. doi: 10.1021/ml300472n

Table 2.

Antiprion potency (EC50) and cell viability (LC50) for selected arylpiperazine analogs.

compd R1 R2 EC50 ± SEM (μM)a LC50 (μM)a
38 >10 >10
39 >10 >10
40 graphic file with name nihms460922t1.jpg graphic file with name nihms460922t2.jpg >10 >10
41 graphic file with name nihms460922t3.jpg graphic file with name nihms460922t4.jpg 0.25 ± 0.03 >10
42 graphic file with name nihms460922t5.jpg graphic file with name nihms460922t6.jpg 3.28 ± 0.49 >10
43 graphic file with name nihms460922t7.jpg graphic file with name nihms460922t8.jpg 4.17 ± 2.19 >10
44 graphic file with name nihms460922t9.jpg graphic file with name nihms460922t10.jpg 0.38 ± 0.02 >10
45 graphic file with name nihms460922t11.jpg graphic file with name nihms460922t12.jpg >10 >10
46 graphic file with name nihms460922t13.jpg graphic file with name nihms460922t14.jpg 0.38 ± 0.02 >10
47 graphic file with name nihms460922t15.jpg graphic file with name nihms460922t16.jpg 1.12 ± 0.58 >10
a

Number of tests for EC50 and LC50 measurement: 3