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In vivo PK parameters and in vitro microsomal stability for arylpiperazines (single oral dose of 10 mg/kg).
| compd | Brain Exposure | Plasma Exposure | Microsomal Stability | |||
|---|---|---|---|---|---|---|
| Cmax (μM) | AUC (μM*h) | Cmax (μM) | AUC (μM*h) | t1/2 (min) | ||
| Mo | Hu | |||||
| 41 | 3.63 ± 0.85 | 14.20 ± 0.57 | 0.91 ± 0.11 | 4.18 ± 0.60 | 9.2 | 50.2 |
| 44 | 3.03 ± 0.53 | 14.40 ± 0.15 | 0.60 ± 0.01 | 2.68 ± 0.39 | 17.3 | 34.3 |
| 46 | 0.36 ± 0.06 | 1.30 ± 0.18 | 0.40 ± 0.15 | 1.17 ± 0.09 | 7.3 | 43.6 |
| 47 | 1.55 ± 0.78 | 3.03 ± 1.04 | 0.65 ± 0.38 | 1.07 ± 0.47 | 25.2 | >60 |
