Statistical parametric map (SPM-F) displaying significant group × emotion interaction for the amygdala F(2, 87) = 5.18, p = 0.007, pcorrected < 0.05, (kE = 34, MNI x, y, z: 27, 0, −18). Color bars ranging from blue to light yellow represent F statistics. Histogram displaying mean percent mean BOLD signal change (with standard deviations) extracted from the peak voxel of the cluster that reached statistical threshold (right). Results from post hoc comparisons: a: within HC, fearful > happy, p < 0.05. L, left; HBO, Healthy offspring having a parent diagnosed with bipolar disorder (n = 16); HC, Healthy control offspring of healthy parents (n = 15).