PPI results depicting neural connectivity between bilateral ventrolateral prefrontal cortex (VLPFC) and amygdala to happy face distracters in the 2-back memory condition of the Emotional Face N-back task. Statistical parametric map (SPM-T) displaying a significant between-group contrast. Relative to HC, HBO exhibited significantly reduced positive functional connectivity between right VLPFC seed and left amygdala (MNI x, y, z: −24, −6, −18), T29 = 2.77, pcorrected < 0.05, kE = 34, and between right VLPFC seed and left dorsolateral prefrontal cortex (MNI x, y, z: −39, −6, 57); T29 = 3.85, pcorrected < 0.05, kE = 160. Histograms on the right displays mean eigenvalues extracted from the peak voxel of the cluster that reached statistical threshold. Color bars ranging from dark blue to yellow represent T statistics. L, left; HBO, Healthy offspring having a parent diagnosed with bipolar disorder (n = 16); HC, Healthy control offspring of healthy parents (n = 15).