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. Author manuscript; available in PMC: 2013 Oct 17.
Published in final edited form as: J Neurosci. 2013 Apr 17;33(16):6944–6949. doi: 10.1523/JNEUROSCI.0643-13.2013

Figure 2. Model of a molecular network necessary for LTF.

Figure 2

A, Grey shading indicates components of the model originally developed by Zhang et al. (2012). The model was extended by incorporating CREB1, CREB2, C/EBP and CBP. Phosphorylation of CREB1 and its subsequent binding to CBP were assumed necessary for induction of c/ebp. Unphosphorylated CREB2 repressed c/ebp. Phosphorylation of CREB2 removed this repression. Arrows and circles indicate positive and negative regulation of transcription, respectively. B–C, Simulations of the Standard Protocol with normal CBP levels (B) and with the CBP knockdown (C). The Rescue Protocol with the CBP knockdown boosted pC/EBP levels beyond control levels (dashed/dotted line) (D).