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. Author manuscript; available in PMC: 2013 Oct 24.
Published in final edited form as: J Neurosci. 2013 Apr 24;33(17):7439–7450. doi: 10.1523/JNEUROSCI.4506-12.2013

Figure 4.

Figure 4

mTOR cascade components in GFAPTg;Gfap+/R236H (Tg/KI) and WT mice. A. Progressive accumulation of p-S6 (235/236) immunopositive astrocytes in Tg/KI from 1 week to 4 weeks. Note that 1 week and 4 week WT astrocytes do not show p-S6 immunoreactivity; the immunopositive cells in str.rad and str.lac-mol in the WT hippocampus are interneurons, and the pyramidal neurons are also positive. B. Positive immunostaining with p-S6(240/244) of astrocytes in GFAPTg;Gfap+/R236H but not in the WT mouse. B1, Note that some enlarged astrocytes with high levels of GFAP do not show p-S6 immunolabeling (arrows). C, Expression of 4E-BP1 and GFAP in WT and GFAPTg;Gfap+/R236H mice. Confocal microscopy. All scale bars 125 µm, except B1 and B1’ (35µm).