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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: J Innate Immun. 2012 Sep 14;5(2):124–136. doi: 10.1159/000342430

FIGURE 8.

FIGURE 8

Model of the multiple molecular mechanisms F. tularensis LVS may utilize to inhibit human neutrophil apoptosis. LVS modulates expression of genes that can down-regulate the extrinsic (death receptor) and intrinsic (mitochondrial) apoptotic pathways, and up-regulates expression of NF B-dependent cell survival genes. At the same time, blockade of NADPH oxidase activity at the F. tularensis phagosome and downregulation of BAX prevent induction of the ROS-dependent phagocytosis-induced cell death (PICD) pathway. Where protein and gene names differ, gene names are shown in parentheses.