Table 1.

Clinical and Pathologic Diagnoses^a

No.	Age at Death	Clinical Diagnosis	Pathologic Diagnosis	Comments
Alzheimer’s disease
1	62.6	AD possible	High probability AD	Infrequent limbic LBs
2	59.7	AD probable	High probability AD	Infrequent brainstem and limbic LBs
3	75.5	AD probable	High probability AD	Brainstem, limbic, and neocortical LBs
4	90.5	AD probable	High probability AD	Amyloid angiopathy
5	66.3	AD probable	High probability AD	Brainstem, limbic, and neocortical LBs; amyloid angiopathy
6	69.0	AD probable	High probability AD	Brainstem, limbic, and neocortical LBs; possible amyloid angiopathy
7	62.8	AD probable (PCA)	High probability AD
8	73.2	AD/DLB probable	High probability AD	Neurofibrillary degeneration of brainstem nuclei
9	68.1	DLB probable	High probability AD	Brainstem, limbic, and neocortical LBs
10	61.9	bvFTD	High probability AD
11	56.8	bvFTD	High probability AD	Neurofibrillary degeneration of brainstem nuclei
Frontotemporal lobar degeneration
1	56.9	bvFTD	FTLD-DLDH
2	74.4	bvFTD	Pick’s (FTLD-T)
3	72.1	bvFTD	Pick’s (FTLD-T)
4	68.3	bvFTD	Pick’s (FTLD-T)	Moderate neuritic plaques; remote infarct frontal subcortical white matter
5	69.7	bvFTD	Pick’s (FTLD-T)	Severe intracranial atherosclerosis with white matter ischemia
6	58.8	bvFTD	Pick’s (FTLD-T)
7	61.6	bvFTD	Pick’s (FTLD-T)
8	78.3	SD	Tauopathy NOS (FTLD-T)	Tau-positive grains and threads, mainly in hippocampus and temporal neocortex
9	53.5	bvFTD	FTLD-U/TDP-43
10	76.8	SD	FTLD-U	TDP-43 stain not done
11	58.4	SD	FTLD-U/TDP-43
12	73.5	SD	FTLD-U/TDP-43
13	77.2	AD-MND vs PNFA-MNDb	FTLD-U	Spinal cord not available; TDP-43 stain not done
14	63.5	FTD-MND	FTLD-U/TDP-43	Spinal cord not available
15	59.5	FTD-MND	FTLD-U/TDP-43	Spinal cord not available
16	53.3	FTD-MND	FTLD-MND (FTLD-U/TDP-43)	Remote infarcts left temporal pole and left orbital frontal cortex
17	59.3	FTD-MND	FTLD-MND (FTLD-U/TDP-43)
18	53.1	PNFA-MNDc	FTLD-MND (FTLD-U/TDP-43)

Note: AD = Alzheimer’s disease; FTLD = frontotemporal lobar degeneration; DLB = dementia with Lewy bodies; bvFTD = behavioral-variant frontotemporal dementia; MND = motor neuron disease; SD = semantic dementia; PNFA = progressive nonfluent aphasia; FTLD-DLDH = FTLD with dementia lacking distinctive histology; FTLD-T = FTLD with tau-positive inclusions; FTLD-U = FTLD with ubiquitin-positive/tau-negative inclusions; FTLD-U/TDP-43 = FTLD with ubiquitin and TDP-43 positive inclusions; FTLD-MND = FTLD that also meets pathologic criteria for motor neuron disease; NOS = not otherwise specified; LBs = Lewy bodies.

^aAge at death is shown in years. Clinical diagnosis refers to diagnosis at the time of MRI. Clinical diagnosis did not change by autopsy unless otherwise specified.

^bDiagnosis at autopsy was FTD-MND.

^cDiagnosis at autopsy was AD-MND versus PNFA-MND.