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Metabolic stability study of carbamothioylacrylamide compounds in liver microsomes. Two representative carbamothioylacrylamide compounds (TG6-129 and compound 6 were tested for metabolic stability at 1 µM or 10 µM in pooled mouse (A) or human (B) liver microsomes with midazolam as a control. The metabolic stability of compounds was expressed as half-life (t1/2) in liver microsomes. Data are shown as mean ± SEM (n = 3).
