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. Author manuscript; available in PMC: 2014 Jul 11.
Published in final edited form as: ACS Med Chem Lett. 2013 May 20;4(7):616–621. doi: 10.1021/ml400112h

Scheme 1.

Scheme 1

Synthesis of (E)-N-((4-(N-(5-ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl)phenyl)carbamothioyl)-3-(4-fluorophenyl)acrylamide (TG6-129). i. Pyridine, 95%. ii. Tin-chloride dihydrate in ethyl acetate at reflux, 70%. iii. Ammoniumthiocyanate in acetone at reflux, 80%.