Skip to main content
. Author manuscript; available in PMC: 2014 Jul 11.
Published in final edited form as: ACS Med Chem Lett. 2013 May 20;4(7):616–621. doi: 10.1021/ml400112h

Table 1.

EP2 potency, selectivity and cytotoxicity of carbamothioylacrylamide derivativesa

Entry PubChem
SID or
vendor ID		 Structure KB
(nM)
EP2		 KB
(nM)
IP		 KB
(µM)
DP1		 KB
(µM)
EP4		 CC50
(µM)
1 (TG6-129) 17,503,974 graphic file with name nihms484539t1.jpg 8.8 199 14.6 3.9 326
2 17,505,080 graphic file with name nihms484539t2.jpg 16.7 57 9.8 5.8 370
3 17,505,097 graphic file with name nihms484539t3.jpg 34.5 360 46.6 13.0 365
4 24,782,326 graphic file with name nihms484539t4.jpg 33.1 2,260 10.3 2.6 330
5 17,508,450 graphic file with name nihms484539t5.jpg 23.1 1,730 16.1 7.8 186
6 26,671,393 graphic file with name nihms484539t6.jpg 18.0 3,250 Inactive 18.2 378
7 17,504,270 graphic file with name nihms484539t7.jpg 13.3 360 Inactive 20.5 150
8 17,504,776 graphic file with name nihms484539t8.jpg 108 21,000 8.7 0.7 96
9 17,508,802 graphic file with name nihms484539t9.jpg 132 5900 25.2 3.1 258
a

EP2, EP4, IP and DP1 KB values are average from 2–5 independent experiments. In vitro half-maximal cytotoxic concentration (CC50) values are from one experiment run in quadruplicate measurements.