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. Author manuscript; available in PMC: 2013 Nov 29.
Published in final edited form as: J Neurosci. 2013 May 29;33(22):9451–9461. doi: 10.1523/JNEUROSCI.5730-12.2013

Figure 9. Chronic, but not acute D1DR stimulation decreases NMDAR-mediated currents.

Figure 9

A) and B) Time-course of whole-cell responses to NMDA (100 µM) before and after pre-treatment with SKF38393 in saline controls and cocaine-experienced animals. C) Summary histograms of whole-cell NMDA responses expressed as current density (t(32)=2.1; *, p<0.05 vs. non-treated saline; n=17–25 cells). D) A summary of eEPSCs (Evoked) and whole-cell NMDAR responses during acute application of SKF38393. In the majority of cells, NMDAR-mediated currents are potentiated during SKF38393 application.