Table 1.
Individual data points for the neuroinflammatory marker gene expression. Bolded font shows points that are statistically significantly greater than saline injected mice at the same time-point, Boxed time-points illustrate the peak change for that gene. Italicized font shows points that are statistically significantly lower than saline injected mice at the same time-point.
| T'ment | Survival | M1 | M2a | M2b | M2c | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| IL1β | Marco | TNFα | AG1 | IL1Ra | YM1 | CD86 | FcγR1 | FcγR3 | Sphk1 | TGFβ | ||
| Anti-Aβ | 1d | 2.6± 0.5 | 0.8± 0.3 | 1.4± 0.3 | 1.3± 0.1 | 0.8± 0.2 | 1.0± 0.2 | 2.1± 0.5 | 3.0± 0.5 | 4.7± 1.1 | 1.9± 0.5 | 1.9± 0.3 |
| 3d | 5.4± 0.8 | 4.6± 0.5 | 3.7± 0.9 | 0.4± 0.1 | 0.4± 0.2 | 0.2± 0.1 | 6.5± 1.5 | 6.0± 1.1 | 2.0± 0.3 | 0.8± 0.3 | 0.7± 0.1 | |
| 7d | 0.9± 0.2 | 2.3± 0.3 | 0.65± 0.3 | 1.7± 0.3 | 1.0± 0.3 | 1.2± 0.3 | 1.1± 0.1 | 0.2± 0.1 | 0.1± 0.05 | 3.2± 0.9 | 9.5± 2.3 | |
| 14d | 1.2± 0.4 | 1.2± 0.5 | 1.0± 0.2 | 1.1± 0.3 | 1.1± 0.2 | 1.2± 0.1 | 0.9± 0.3 | 0.5± 0.3 | 0.45± 0.3 | 1.1± 0.3 | 3.2± 1.1 | |
| 21d | 1.2± 0.3 | 0.9± 0.3 | 1.1± 0.2 | 1.2± 0.2 | 1.2± 0.2 | 1.5± 0.5 | 1.5± 0.2 | 1.1± 0.3 | 1.1± 0.3 | 1.3± 0.2 | 1.1± 0.3 | |
| IVIg | 1d | 1.5± 0.6 | 1.6± 0.6 | 1.1± 0.6 | 1.3± 0.3 | 1.3± 0.3 | 1.2± 0.3 | 0.9± 0.2 | 1.2± 0.3 | 1.3± 0.5 | 1.5± 0.6 | 1.3± 0.3 |
| 3d | 2.3± 0.5 | 1.9± 0.3 | 1.2± 0.5 | 1.3± 0.5 | 0.7± 0.3 | 1.1± 0.3 | 1.1± 0.3 | 2.3± 0.5 | 4.0± 0.6 | 1.3± 0.2 | 1.5± 0.3 | |
| 7d | 5.6± 0.5 | 3.7± 0.3 | 3.4± 0.3 | 0.3± 0.1 | 0.3± 0.2 | 0.3± 0.1 | 3.9± 0.9 | 3.5± 0.3 | 1.4± 0.6 | 1.0± 0.2 | 1.3± 0.2 | |
| 14d | 3.6± 0.9 | 2.2± 0.3 | 1.1± 0.4 | 0.7± 0.2 | 0.7± 0.2 | 0.5± 0.1 | 0.9± 0.2 | 0.3± 0.2 | 0.7± 0.3 | 2.5± 0.5 | 3.3± 0.9 | |
| 21d | 1.4± 0.3 | 1.3± 0.5 | 1.5± 0.6 | 0.8± 0.1 | 1.3± 0.2 | 1.1± 0.2 | 1.3± 0.7 | 0.8± 0.3 | 1.1± 0.4 | 1.2± 0.3 | 1.1± 0.3 | |
| M-IgG | 1d | 1.4± 0.5 | 1.5± 0.5 | 1.2± 0.5 | 1.2± 0.5 | 1.5± 0.3 | 1.1± 0.3 | 1.0± 0.3 | 1.2± 0.5 | 0.9± 0.4 | 0.8± 0.2 | 0.7± 0.3 |
| 3d | 2.9± 0.6 | 1.3± 0.5 | 1.1± 0.3 | 1.2± 0.3 | 1.0± 0.3 | 1.2± 0.3 | 2.1± 0.4 | 3.5± 0.9 | 3.9± 0.5 | 1.2± 0.4 | 1.2± 0.3 | |
| 7d | 4.2± 0.4 | 3.9± 0.6 | 3.8± 0.4 | 0.7± 0.2 | 0.4± 0.2 | 0.3± 0.2 | 3.2± 0.6 | 4.1± 0.5 | 1.5± 0.4 | 0.8± 0.5 | 0.9± 0.3 | |
| 14d | 2.9± 0.3 | 2.7± 0.4 | 0.7± 0.3 | 0.9± 0.3 | 0.9± 0.1 | 0.6± 0.2 | 1.2± 0.5 | 0.4± 0.2 | 0.3± 0.2 | 2.1± 0.8 | 2.6± 0.7 | |
| 21d | 1.5± 0.5 | 1.2± 0.3 | 1.0± 0.2 | 1.2± 0.2 | 1.1± 0.3 | 1.5± 0.3 | 1.2± 0.3 | 0.9± 0.3 | 1.1± 0.3 | 0.9± 0.3 | 0.9± 0.3 | |