Figure 7. Interneurons are not synchronous during low frequency oscillations.

A, Thalamic activation of cortical neurons in two different UP states regimes. Recordings were made from pvGFP interneurons and PCs in ACSF with either normal K⁺ (top trace, black) or high K⁺ (bottom trace, purple). The thalamus was stimulated in both of these conditions, and the response to this stimulation is shown in the expanded traces to the right. B, the frequency of UP states in high K⁺ was significantly higher than normal K⁺. C. the duration of the UP state was significantly shorter in high K⁺ vs. normal K⁺ for both spontaneous (‘spont’) and thalamically stimulated (‘stim’) UP states. No significant difference was found when comparing spont vs. stim in either high K⁺ or normal K⁺. D, the number of action potentials fired by PV cells and PCs during the UP state was significantly lower in high K⁺ vs. normal K⁺ for both spont and stim UP states. No significant difference was found when comparing spont vs. stim in either high K⁺ or normal K⁺. ** indicate significance p < 0.001, * indicates p < 0.01. E, Distributions of minimum intercell spike intervals for pvGFP interneurons in high K⁺ for both spont (left) and stim (right) conditions. F, Distributions of minimum intercell spike intervals for PCs in high K⁺ for both spont (left) and stim (right) conditions. No significant difference was found when comparing pvGFP vs PC distributions in spont and stim conditions.