Figure 2. Impaired motor function and motor learning ability of homozygous Dscam^del17 mutant mice.

(A) In the rotarod test, at 0 s, three groups of mice with different genotypes were placed on the resting rod (A1). At 35 s, homozygous Dscam^del17 mutant mice fell off (A2). At 102 s, the heterozygous Dscam^del17 mutant mice fell off (A3). (B and C) Motor function as measured by the rotarod test. The average running duration on the rotarod of wild type and heterozygous Dscam^del17 mutant mice were significant longer than the homozygous Dscam^del17 mutant mice (means ± SEM, One-way ANOVA and Bonferrioni’s multiple comparison test, **p < 0.01; ***p < 0.001).As compared with the wild type and heterozygous Dscam^del17 mutant mice, homozygous Dscam^del17 mutant mice fell off at a lower speed (means ± SEM, One-way ANOVA and Bonferrioni’s multiple comparison test, ***p < 0.001). (D) The average running duration of mice after training. After training, the average running duration of the wild type mice was significantly extended, whereas that of heterozygous Dscam^del17 mutant mice and homozygous Dscam^del17 mutant mice had no significant difference before and after training (means ± SEM, Two-way ANOVA and Bonferroni posttests, *p < 0.05; ns, no significance) [Wt, wild type; het(+/−), heterozygous Dscam^del17 mutant mice; hm(−/−), homozygous Dscam^del17 mutant mice].