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. Author manuscript; available in PMC: 2014 Aug 8.
Published in final edited form as: ACS Med Chem Lett. 2013 Jun 10;4(8):762–767. doi: 10.1021/ml400166b

Scheme 3a.

Scheme 3a

aReagents and conditions: (a) Br2, AcOH. (b) NH2Me, CH2Cl2. (c) HCl, MeOH. (d) NaSCN, DMF, 160 °C. (e) BrCH2R’, Cs2CO3, DMF. (f) N-bromosuccinimide, CCl4. (g) m-chloroperoxybenzoic acid, CH2Cl2. (h) R”B(OH)2, Na2CO3, Pd(PPh3)4.