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. Author manuscript; available in PMC: 2013 Aug 15.
Published in final edited form as: J Neurosci. 2013 Jan 2;33(1):358–370. doi: 10.1523/JNEUROSCI.2425-12.2013

Figure 2. Sortilin deficiency does not impact α- and β-secretase activities.

Figure 2

(A, B) Quantitative analysis of carboxyl terminal fragments (CTF) C99 and C83 in total brain extracts of Sort1+/+ and Sort1−/− mice on the PDAPP background using Western blotting (A) and densitometric scanning of replicate blots (B, n=7–11 per genotype). Detection of APP and tubulin served as loading controls in A. (C) Activity of β-site APP cleaving enzyme (BACE)1 in mice of the indicate genotypes using FRET assay as described in Methods (n=4 per group). RFU, relative fluorescent unit.