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Burstiness during closed-loop control of tonic firing rate. A, After an initial period of ∼15 sec during which the feedback algorithm settles, burst control was perfect at the higher target firing rates (f.r.). A culture at 43 DIV was used. (This culture was not tested at 800 SPSA.) B, Burstiness index decreased monotonically with the target rate and was always below the spontaneous level (◯). Values are mean ± SEM from n = 85 runs using different sets of electrodes on 10 cultures.
