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. Author manuscript; available in PMC: 2013 Oct 16.
Published in final edited form as: Eur J Immunol. 2012 Dec 13;43(2):540–549. doi: 10.1002/eji.201242804

Figure 4.

Figure 4

Chemokine concentration of RANTES, MIP-1β and MIP-1α in serum and bronchoalveolar lavage (BAL) of HIV-1 infected (n=15, open squares) or HIV-1 uninfected (=20, solid circles) persons. Chemokine concentration was measured by multiplex bead array, each sign represents one sample, bars represent medians. (A) Differences of RANTES concentration between paired serum and BAL samples of HIV-1 infected (p<0.001) and HIV-1 uninfected persons were assessed by Wilcoxon signed rank test. The RANTES level in BAL in HIV-1 infected in comparison with HIV-1 uninfected (p<0.001) was calculated by Mann Whitney U test. (B) Difference of MIP-1β concentration between paired serum and BAL samples of HIV-1 infected participants (p<0.001) was assesses by Wilcoxon signed rank test. MIP-1β level in BAL was higher in HIV-1 infected versus HIV-1 uninfected persons (p=0.004, Mann Whitney U test). (C) Wilcoxon signed rank test was used to compare MIP-1α level in paired blood and BAL samples (p<0.001 in HIV-1 infected, p=0.01 in HIV-1 uninfected persons). (D) Correlation between RANTES concentration in BAL and viral load (VL) in BAL were assessed by Spearman (rho=0.635, p=0.011). Open circles, BAL VL; symbol x, BAL VL lower detection limit (LDL) were set to a value of 19 copies/mL and normalized according to the Urea method.