Table 2.

Association of colon adenomas and circulating IL-6 and TNF-alpha.

Category*	Caucasian				African-American				All subjects
	Cases n=227	Controls n=667	Crude OR (95% CI)	Adjusted OR** (95% CI)	Cases n=174	Controls n=383	Crude OR (95% CI)	Adjusted OR** (95% CI)	Cases n=401	Controls n=1050	Crude OR (95% CI)	Adjusted OR*** (95% CI)
IL-6
Tertile 1	73	224	1.00	1.00	62	129	1.00	1.00	113	352	1.00	1.00
Tertile 2	67	221	0.93 (0.64–1.36)	0.77 (0.52–1.16)	43	128	0.70 (0.44–1.11)	0.58 (0.36–0.95)	136	348	1.22 (0.91–1.63)	1.06 (0.78–1.44)
Tertile 3	87	222	1.20 (0.84–1.73)	0.87 (0.57–1.32)	69	126	1.14 (0.75–1.74)	1.00 (0.62–1.61)	152	350	1.35 (1.02–1.80)	1.01 (0.72–1.40)
p for trend			0.05	0.53			0.08	0.13			0.002	0.10
TNF-α
Tertile 1	71	222	1.00	1.00	51	128	1.00	1.00	123	350	1.00	1.00
Tertile 2	66	223	0.93 (0.63–1.36)	0.78 (0.52–1.16)	54	128	1.06 (0.67–1.67)	1.06 (0.66–1.71)	120	351	0.97 (0.73–1.30)	0.85 (0.63–1.15)
Tertile 3	90	222	1.27 (0.88–1.82)	0.94 (0.63–1.39)	69	127	1.36 (0.88–2.11)	1.14 (0.72–1.81)	158	349	1.29 (0.98–1.70)	1.01 (0.75–1.36)
p for trend			0.23	0.20			0.78	0.55			0.20	0.39

^*For Caucasians, the IL-6 cutoffs were 1.25 pg/ml & 2.22 pg/ml; for African American, 2.00 pg/ml & 3.83 pg/ml; for all subjects, cutoffs were 1.44 pg/ml & 2.71 pg/ml. For Caucasian, the TNF-α cutoffs were 3.02 pg/ml & 4.50 pg/ml; for African Americans, 3.00 pg/ml & 4.42 pg/ml; for all subjects, cutoffs were 3.01pg/ml &4.46 pg/ml.

^**Adjusted for age, sex, non-steroidal anti-inflammatory use, BMI, family history of colorectal cancer, and smoking status.

^***Also adjusted for race.