Skip to main content

View full-text article in PMC

. Author manuscript; available in PMC: 2014 Aug 8.

Published in final edited form as: ACS Med Chem Lett. 2013 Jul 3;4(8):779–783. doi: 10.1021/ml400175d

Table 3.

HDAC Profiling of Chimera 4 and Vorinostat

	HDAC Class	IC₅₀ (nM), Chimera 4	IC₅₀ (nM), Vorinostat^a
HDAC1	I	86 ± 11	306
HDAC2	I	231 ± 39	232
HDAC3	I	19 ± 1	132
HDAC4	IIa	3,982 ± 920	76,000
HDAC5	IIa	3,891 ± 681	27,200
HDAC6	IIb	2.7 ± 0.5	20
HDAC7	IIa	13,220 ± 860	105,000
HDAC8	I	2,311 ± 251	306
HDAC9	IIa	28,020 ± 1,910	141,000
HDAC10	IIb	51 ± 3	432
HDAC11	IV	224 ± 26	200

^a

Data from Reaction Biology (Malvern, PA).