Table 1.

Select component	Phase(s)	Cellular expression	Key growth factor(s)	Function
Collagen I	Hemostasis	Epithelial, endothelial, fibroblast, smooth muscle, leukocytes, platelets	bFGF	Tissue architecture
	Inflammatory		TGF-β	Tensile strength
	Tissue formation		PDGF	Cell–matrix and matrix–matrix interaction
	Tissue remodeling		EGF	ECM remodeling
Collagen III	Hemostasis	Epithelial, endothelial, fibroblast, leukocytes, platelets	EGF	Tissue architecture
	Inflammatory		TGF-β	Matrix–matrix interaction
	Tissue formation		PDGF	Maturation and ECM remodeling
			EGF
Fibrinogen	Hemostasis	Platelets, leukocytes, endothelial, fibroblast	FGF-2	Cell–cell interaction
	Inflammatory		VEGF	Cell–matrix
	Tissue formation			Platelet–protein
				Cell proliferation
				Cell migration
Hyaluronan	Tissue formation	Epithelial, fibroblast, smooth muscle	TGF-β1	Cell–matrix interactions
	Tissue remodeling		EGF	Matrix–matrix interactions
			Chemokines	Cell proliferation
				Cell migration
Fibronectin	Hemostasis	Epithelial, endothelial, fibroblast, leukocytes, platelets	PDGF	Tissue architecture
	Inflammatory		Chemokines	Cell–matrix and matrix–matrix interactions
	Tissue formation			Cell proliferation and migration
	Tissue remodeling			Opsonin
Tenascin C	Tissue formation	Epithelial, fibroblast	EGF-like repeats	Modulates cell–matrix
	Tissue remodeling		TGF-β	Anti-adhesive
			Chemokines	Anti-proliferative
Decorin	Tissue formation	Fibroblast	EGF	Cell–matrix interactions
	Tissue remodeling		TGF-β1	Matrix–matrix interactions
			Chemokines	Bind and storage of growth factors
				Cell proliferation
Entactin (or nidogen)	Hemostasis	Epithelial, fibroblast, neutrophil	EGF	Basement membrane component
	Inflammatory			Stabilizes basement membrane
	Tissue formation
Laminin	Hemostasis	Epithelial, endothelial, fibroblast, smooth muscle, platelets, neutrophil, monocyte	EGF	Basement membrane component
	Inflammatory		Chemokines	Cell migration
	Tissue formation
	Tissue remodeling
Collagen IV	Tissue formation	Epithelial, endothelial, fibroblast, smooth muscle, platelets, neutrophil, monocyte	EGF	Basement membrane component
	Tissue remodeling		Chemokines	Cell migration