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. Author manuscript; available in PMC: 2008 Jul 16.
Published in final edited form as: J Biol Chem. 2008 Apr 14;283(23):15577–15588. doi: 10.1074/jbc.M802035200

Fig. 6.

Fig. 6

Comparison of inactivation of the β2CED- and β2d-modulated calcium channels with Ca2+ and Ba2+ as the charge carrier. A and B. Comparison of ICa and IBa recorded from COS1 cells expressing α1C,77/α2δ and β2d (A) or β2CED (B). Current traces were normalized to the maximum amplitude of the respective ICa. One can see that ICa inactivated much faster than IBa in the case of β2d, but not β2CED, thus confirming that β2CED does not support CDI. C and D. Comparison of IBa (C) and ICa (D) through the α1C,77/α2δ channels modulated by β2CED or β2d. The traces were normalized to the maximum amplitude of ICa through the α1C,77/α2δ/β2CED (C) and α1C,77/α2δ/β2d (D) channels. Unlike CDI, voltage-dependent inactivation of the channel supported by β2CED was not markedly changed. Currents were recorded at Vt = +20, +30 and +40 mV applied from Vh = −90 mV.