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Developing Selective type II kinase inhibitors. A. Docking imatinib into the X-ray co-crystal structure of DDR1; B. Chemical structure of DDR1-IN-1/2 and representative developing rationale; C. DDR1-IN-1 efficacy on blocking DDR1 auto-phosphorylation; D.DDR1-IN-2 efficacy on blocking DDR1 auto-phosphorylation; E. KinomeScan™ TreeSpot description of the DDR1-IN-1/2 selectivity profile.
