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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Biochim Biophys Acta. 2013 Sep 18;1838(4):1058–1067. doi: 10.1016/j.bbamem.2013.09.004

Figure 2. The funnel architecture and pore elements of the p7 channel.

Figure 2

(A) NMR structure of the p7 hexamer. Left panel: cartoon (cylinder) representation illustrating the funnel architecture of the channel. Right panel: global arrangement of H1, H2 and H3 helical segments in the assembled hexamer, showing that the i and i+3 monomers form a symmetric pair in the hexamer.

(B) Pore-lining elements of the p7 channel. Left panel: cutaway view of the channel showing the pore-lining residues, with residues in red being strongly conserved. The numbers next to the helical segments represent the monomers to which the helices belong. Right panel: the view of the N-terminal opening of the channel showing the carboxamide ring formed with Asn9 sidechains.