Table II.

Interaction of genotypes with cigarette smoking in non-Hispanic white participants

Genotype	Smoke (pack-years)	Male			Female
		Cases/controls, n	OR (95% CI)a	Pinteraction	Cases/controls, n	OR (95% CI)a	Pinteraction
CYP1A2*1F				0.805			<0.001
AC/CC	Never	60/62	1.0		55/79	1.0
AA	Never	78/86	0.99 (0.61–1.60)		60/62	1.35 (0.80–2.25)
AC/CC	≤20	50/43	1.11 (0.64–1.94)		31/27	1.51 (0.78–2.91)
AA	≤20	42/47	0.94 (0.53–1.64)		35/24	2.31 (1.21–4.42)
AC/CC	>20	74/44	1.75 (1.03–2.97)		38/22	2.24 (1.15–4.38)
AA	>20	81/72	1.06 (0.64–1.73)		45/16	4.36 (2.15–8.84)
Ptrend			0.430			<0.001
SULT1A1				0.023			<0.001
GG	Never	59/52	1.0		43/53	1.0
GA/AA	Never	79/96	0.76 (0.47–1.25)		72/89	0.97 (0.57–1.65)
GG	≤20	27/33	0.73 (0.38–1.41)		19/21	1.00 (0.46–2.19)
GA/AA	≤20	60/53	0.94 (0.54–1.62)		43/30	1.91 (1.00–3.62)
GG	>20	49/48	0.84 (0.48–1.47)		38/19	2.45 (1.18–5.08)
GA/AA	>20	97/69	1.21 (0.72–2.01)		44/18	2.96 (1.45–6.06)
Ptrend			0.330			<0.001
NAT1				0.408			0.012
Non*10	Never	88/101	1.0		70/96	1.0
*10	Never	50/47	1.22 (0.74–2.02)		45/46	1.34 (0.78–2.29)
Non*10	≤20	62/56	1.18 (0.73–1.89)		45/38	1.64 (0.93–2.87)
*10	≤20	25/30	0.92 (0.49–1.73)		17/13	1.98 (0.89–4.44)
Non*10	>20	97/82	1.24 (0.81–1.90)		55/27	2.71 (1.50–4.89)
*10	>20	49/35	1.55 (0.91–2.66)		27/10	4.01 (1.73–9.29)
Ptrend			0.300			<0.001
NAT2				0.021			0.002
R/I	Never	62/53	1.0		56/65	1.0
Slow	Never	76/95	0.65 (0.40–1.06)		59/77	0.81 (0.48–1.36)
R/I	≤20	39/38	0.80 (0.44–1.45)		23/21	1.47 (0.72–3.03)
Slow	≤20	48/48	0.77 (0.44–1.37)		39/30	1.34 (0.71–2.53)
R/I	>20	58/51	0.87 (0.51–1.51)		39/16	2.71 (1.30–5.65)
Slow	>20	88/66	1.03 (0.62–1.71)		43/21	2.27 (1.16–4.46)
Ptrend			0.622			0.001

R/I = rapid/intermediate.

^aOR was adjusted for age, family history of cancer, history of diabetes and alcohol consumption.