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. Author manuscript; available in PMC: 2014 Nov 15.
Published in final edited form as: Bioorg Med Chem Lett. 2013 Sep 7;23(22):10.1016/j.bmcl.2013.08.112. doi: 10.1016/j.bmcl.2013.08.112

Scheme 2.

Scheme 2

Synthesis of P2-P1 analogs 12 and 13a–l. Reagents and conditions: (a) MeOH, 50 °C 4h, 94%, (b) TFA, 95% (c) (i) HATU, DIPEA, DMF, RCO2H, 55–73% (d) RCO2Cl or RSO2Cl, TEA, DCM, 51–64%. Final library compounds were purified by UV prep or mass-directed prep HPLC.