Table 2.

Novel targets in viral gene products for drug development

Virus	Target	Function
Flaviviruses	protease	Processing of precursor polyprotein
	Helicase	Initiation of viral replication
	Methyltransferase	Needed to form mature RNA cap structure
	RNA-dependent RNA polymerase	Synthesis of minus strand RNA
	unknown
HIV	Tat	transactivation of HIV genome
Herpes	helicase	Unwind viral DNA to initiate replication
	Terminase	Helps package DNA into the capsid
JC virus	T antigen	Regulatory protein
	Agnoprotein	Regulatory protein
	VP-1	Core protein