. Author manuscript; available in PMC: 2013 Dec 30.

Published in final edited form as: Clin Nephrol. 2012 Sep;78(3):174–180. doi: 10.5414/CN107427

Table 4.

Associations of APOE alleles with rapid progression.

	APOE allele OR (95% CI)
	ε3	ε2	ε4
eGFRcreat > 3 ml/min/1.73 m²/year
N	2,179	437	710
#with rapid decline	248	49	79
Unadjusted	1.00 (reference)	0.91 (0.68, 1.22)	0.89 (0.69, 1.13)
Age + gender adjusted	1.00 (reference)	0.88 (0.66, 1.19)	0.91 (0.71, 1.16)
Fully adjusted^*	1.00 (reference)	0.87 (0.64, 1.17)	0.95 (0.74, 1.22)
eGFRcys > 3ml/min/1.73 m²/year
N	2179	437	710
#with rapid decline	450	99	158
Unadjusted	1.00 (reference)	1.08 (0.87, 1.34)	1.13 (0.95, 1.36)
Age + gender adjusted	1.00 (reference)	1.07 (0.86, 1.33)	1.16 (0.97, 1.39)
Fully adjusted^*	1.00 (reference)	1.08 (0.87, 1.36)	1.19 (0.99, 1.43)

Fully adjusted model includes age, gender, diabetes, systolic blood pressure, diastolic blood pressure, antihypertensive medications, body mass index and prevalent coronary heart disease, low density lipoprotein, high density lipoproteins, triglycerides, lipid lowering medication use, and smoking status.