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. Author manuscript; available in PMC: 2008 Oct 28.
Published in final edited form as: J Biol Chem. 2008 Jun 5;283(30):21093–21101. doi: 10.1074/jbc.M800431200

Figure 6.

Figure 6

A Model of β-arrestin-PIP5K Iα Coordinated Clathrin-Coated Pit Formation and Receptor Endocytosis. Upper panel. Illustration of β-arrestin (white ribbon structure) recruitment of clathrin (black triskelion) to a GRK-phosphorylated, agonist-occupied 7TMR. Middle panel. β-arrestin binding to the receptor and interactions with PIP2 and PIP3 in the plasma membrane can promote an association with PIP5K Iα. Lower panel. β-arrestin-bound PIP5K Iα localizes to the activated 7TMR where it may enrich the local pool of PIP2. This elevated PIP2 concentration can promote clathrin-AP2 nucleation and 7TMR sequestration as well as other PIP2-dependent processes including the possibility of initiating a feed-forward mechanism of β-arrestin-PIP5K Iα interaction.