Table 3.
Outcome of treatment with donor VSTs in our studies
| Specificity | Virus | Patients | Partial or Complete Response | Failure | References |
|---|---|---|---|---|---|
| Monovirus VSTs with prolonged culture | |||||
| LCL-induced EBV CTLs | EBV | 13 | 11 | 2 | Rooney et al 1995(80) Heslop et al 1996(79) Rooney et al 1998(81) Heslop et al 2010(22) |
| Bivirus VSTs with prolonged culture | |||||
| AD5/35 induced EBV/ADV CTLs | EBV | 1 | 1 | 0 | Leen et al 2009(101) |
| AdV | 2 | 1 | 1 | ||
| Trivirus VSTs with prolonged culture | |||||
| AD5/35pp65 induced CMV/ADV/EBV CTLs | EBV | 6 | 6 | 0 | Leen et al 2006(102) |
| AdV | 6 | 5 | 1 | ||
| CMV | 11 | 10 | 1 | ||
| Trivirus VSTs with rapid culture | |||||
| Plasmid Induced CMV/ADV/EBVs CTLs | EBV | 2 | 2 | 0 | Gerdemann et al 2013(112) |
| AdV | 4 | 4 | 0 | ||
| CMV | 5 | 4 | 1 | ||
| TOTAL | EBV | 22 | 20 | 2 | |
| AdV | 12 | 10 | 2 | ||
| CMV | 16 | 14 | 2 | ||