| DNA-binding Domain | Total members |
|---|---|
| ZF - NHR | 272 |
| ZF - C2H2 | 217 |
| HD | 101 |
| bHLH | 41 |
| novel | 34 |
| bZIP | 33 |
| AT Hook | 29 |
| T-box | 22 |
| MYB | 19 |
| WH - Fork Head | 18 |
| HMG box | 16 |
| ZF - GATA | 14 |
| MADF | 11 |
| ZF - DM | 11 |
| WH - ETS | 10 |
| CBF | 9 |
| ZF - BED | 9 |
| HTH | 7 |
| MH1 | 7 |
| Paired Domain | 7 |
| ZF - THAP | 6 |
| ARID/BRIGHT | 5 |
| COLD BOX | 5 |
| AP-2 | 4 |
| SAND | 4 |
| WH - TDP | 4 |
| ZF - FLYWCH | 4 |
| IPT/TIG | 3 |
| p53 | 3 |
| TSC-22/dip/bun | 3 |
| WH - HSF | 3 |
| Brinker | 2 |
| GC-rich DNA-binding domain | 2 |
| MADS box | 2 |
| PUR | 2 |
| WH | 2 |
| ZF - NF-X1 - 10 domains | 2 |
| CP2 | 1 |
| p66 family | 1 |
| RNT | 1 |
| RPEL | 1 |
| STAT | 1 |
| TEA/ATTS | 1 |
| TRAP230 family | 1 |
| WH - DAC | 1 |
| WH - RFX | 1 |
| YL1 TF | 1 |
| ZF - C2CH | 1 |
| ZF - C2HC | 1 |