Table 2.
Distribution of Selected Histological Findings According to Biochemical Classification at Onset of Suspected DILI
| Biochemical Presentation | ||||||
|---|---|---|---|---|---|---|
| Feature | All Cases | Hepatocellular | Mixed | Cholestatic | p Value | |
| N | 249 | 128 | 48 | 73 | ||
| Interface Hepatitis (mean) | 2.21 | 2.63 | 2.17 | 1.5 | <0.0001 | |
| Lobular Inflammation (mean) | 3.00 | 3.29 | 2.81 | 2.62 | <0.0001 | |
| Portal Inflammation (mean) | 1.66 | 1.87 | 1.58 | 1.36 | 0.008 | |
| Confluent Necrosis (mean) | 1.11 | 1.71 | 0.67 | 0.36 | 0.0003 | |
| Plasma Cells | 56 (23) | 40 (32) | 7 (15) | 9 (12) | 0.002 | |
| Eosinophils | 94 (38) | 60 (48) | 17 (35) | 17 (23) | 0.003 | |
| Lipogranulomas | 47 (19) | 16 (13) | 16 (33) | 15 (21) | 0.008 | |
| Apoptosis | ||||||
| None | 56 (23) | 15 (12) | 15 (31) | 26 (36) | <0.0001 | |
| <1 per 40× hpf | 121 (49) | 52 (41) | 26 (54) | 43 (59) | ||
| 1–3 per 40× hpf | 57 (23) | 47 (37) | 6 (13) | 4 (5) | ||
| >3 per 40× hpf | 13 (5) | 12 (10) | 1 (2) | 0 (0) | ||
| Degree of Necrosis | ||||||
| None | 186 (75) | 83 (65) | 41 (87) | 62 (85) | 0.007 | |
| <5% | 23 (9) | 14 (11) | 1 (2) | 8 (11) | ||
| 5–33% | 20 (8) | 16 (13) | 1 (2) | 3 (4) | ||
| 33–67% | 13 (5) | 10 (8) | 3 (6) | 0 (0) | ||
| >67% | 5 (2) | 4 (3) | 1 (2) | 0 (0) | ||
| Hepatocyte Rosettes | 76 (31) | 57 (45) | 8 (17) | 11 (15) | <0.0001 | |
| Lobular Disarray | 46 (19) | 42 (33) | 2 (4) | 2 (3) | <0.0001 | |
| Fibrosis Stage (mean) | 1.31 | 1.38 | 1.40 | 1.24 | 0.35 | |
| Cholestasis Grade (mean) | 1.71 | 0.68 | 1.08 | 1.53 | <0.0001 | |
| Hepatocellular Cholestasis | 112 (45) | 41 (32) | 23 (48) | 48 (66) | <0.0001 | |
| Canalicular Cholestasis | 120 (48) | 50 (39) | 23 (48) | 47 (64) | 0.003 | |
| Ductal Paucity | ||||||
| None | 231 (95) | 123 (98) | 45 (96) | 63 (89) | 0.02 | |
| Mild | 7 (3) | 0 (0) | 1 (2) | 6 (8) | ||
| Moderate to Marked | 6 (2) | 3 (2) | 1 (2) | 2 (3) | ||
| Portal Venopathy | 10 (4) | 1 (1) | 2 (5) | 7 (10) | 0.008 | |
| Hemorrhage | 25 (10) | 21 (17) | 2 (4) | 2 (3) | 0.003 | |
| Sinusoidal Dilation (moderate to marked) | 12 (5) | 5 (4) | 0 (0) | 7 (10) | 0.04 | |
| Nodular transformation | 10 (4) | 2 (2) | 0 (0) | 8 (11.6) | 0.001 | |
Data is shown as N(%) or as mean values. Means of scores are shown only for simplicity. Chi square analysis was used to determine significance of variation across the three biochemical presentations.