Table 3.
Variation in Selected Histopathologic Features Between the Most Common Injury Patterns
| Acute Hepatitic |
Chronic Hepatitic |
Acute Cholestatic |
Chronic Cholestatic |
Cholestatic Hepatitic |
|
|---|---|---|---|---|---|
| N | 51 | 35 | 23 | 25 | 74 |
| Feature | |||||
| Interface Hepatitis (mean) | 3.14 | 2.69 | 0.61 | 1.88 | 2.22 |
| Lobular Inflammation (mean) | 3.73 | 3.00 | 1.65 | 2.48 | 3.38 |
| Portal Inflammation (mean) | 2.14 | 2.14 | 0.74 | 1.52 | 1.60 |
| Confluent Necrosis (mean) | 2.08 | 1.17 | 0.09 | 0.36 | 1.00 |
| Plasma Cells | 18 (35) | 13 (37) | 0 (0) | 3 (12) | 18 (25) |
| Neutrophils | 16 (31) | 2 (6) | 3 (13) | 6 (24) | 31 (43) |
| Lymphoid Aggregates or Germinal Centers | 7 (14) | 11 (31) | 0 (0) | 2 (8) | 5 (7) |
| Apoptosis | 1.78 | 1.0 | 0.61 | 0.80 | 1.07 |
| Degree of Necrosis (mean) | 0.84 | 0.37 | 0.05 | 0.12 | 0.38 |
| Hepatocyte Rosettes | 27 (54) | 12 (34) | 0 (0) | 5 (20) | 23 (32) |
| Lobular Disarray | 29 (58) | 1 (3) | 0 (0) | 0 (0) | 16 (22) |
| Fibrosis Stage (mean) | 0.94 | 2.31 | 0.59 | 1.52 | 1.11 |
| Grade of Cholestasis (mean) | 0.04 | 0 | 2.09 | 0.84 | 2.07 |
| Hepatocellular Cholestasis | 0 (0) | 0 (0) | 22 (96) | 8 (32) | 68 (92) |
| Canalicular Cholestasis | 3 (6) | 0 (0) | 21 (91) | 8 (32) | 74 (100) |
| Cholate-stasis | 4 (8) | 2 (6) | 4 (17) | 23 (92) | 22 (30) |
| Duct Injury, Multiple Ducts | 20 (40) | 8 (24) | 6 (27) | 18 (78) | 38 (52) |
| Ductal Paucity, Mild or worse | 0 (0) | 0 (0) | 3 (14) | 8 (32) | 2 (3) |
| Portal Venopathy | 1 (2) | 0 (0) | 0 (0) | 4 (17) | 0 (0) |
| Copper | 0.10 | 0.12 | 0.09 | 0.74 | 0.13 |
| Patterns of DILI with Particular Agents (only 1 agent implicated) | |||||
| Amoxicillin/Clavulanate | 1 | 0 | 3 | 3 | 9 |
| Nitrofurantoin | 2 | 4 | 0 | 2 | 1 |
| Minocycline | 3 | 2 | 0 | 0 | 2 |
| Sulfamethoxazole/Trimethoprim | 1 | 0 | 1 | 0 | 4 |
Data is shown as N(%) or as mean values. Means of scores are shown only for simplicity.