. Author manuscript; available in PMC: 2014 Mar 8.

Published in final edited form as: Hepatology. 2013 Dec 18;59(2):661–670. doi: 10.1002/hep.26709

Table 4.

Range of ALT and Alkaline Phosphatase by Injury Pattern

	Labs at biopsy		Zimmerman²
Injury Pattern	ALT/ULN¹	AlkP/ULN¹	ALT/ULN	AlkP/ULN
Acute Hepatitic	12.8–27.4x	1.0–2.9x	10–100x	1–3x
Chronic Hepatitic	3.4–9.5x	0.9–2.3x	3–50x	1–3x
Acute Cholestatic	2.1–10.0x	1.3–3.8x	1–5x	1–3x
Chronic Cholestatic	2.5–11.5x	2.2–8.4x	1–5x	3–20x
Cholestatic Hepatitic	1.7–13.1x	1.2–3.2x	1–10x	>3x
Necrosis (Zonal)	6.4–46.7x	0.9–1.7x	10–1000x	1–3x

Ranges represent 25^th to the 75^th percentile of the laboratory data obtained at the time of liver biopsy, with ALT and AlkP normalized to the local laboratory upper limit of normal.

Ranges adapted from Tables 4.25 and 4.26 on p. 103 of reference (9).