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. Author manuscript; available in PMC: 2009 Jun 13.
Published in final edited form as: J Biol Chem. 2008 Apr 11;283(24):16830–16839. doi: 10.1074/jbc.M801778200

FIGURE 7. AKR1D1-NADP+-cortisone complex: the positions of the natural mutations L106F, P198L, P133R, and R261C.

FIGURE 7

Cortisone, L106, P198, P133, and R261 atoms are black, and NADP+ atoms are magenta. Among these four residues, P133 in loop A is closest to the substrate binding site.