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. Author manuscript; available in PMC: 2015 Feb 13.
Published in final edited form as: ACS Med Chem Lett. 2013 Dec 20;5(2):133–137. doi: 10.1021/ml400370w

Scheme 1.

Scheme 1

Syntheses of the cpAbs a

aReagents and Conditions: (a) S21, THPTA, CuSO4, sodium ascorbate, H2O, t-BuOH, rt, 2 h, 4 100%, 5 67%; (b) mouse mAb 38C2, 100 mM PBS solution (pH 7.4), rt, 2 h.