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. Author manuscript; available in PMC: 2015 Feb 13.
Published in final edited form as: ACS Med Chem Lett. 2013 Dec 20;5(2):133–137. doi: 10.1021/ml400370w

Scheme 2.

Scheme 2

Synthesis of the PEGylated compounds a

aReagents and Conditions: (a) S22, THPTA, CuSO4, sodium ascorbate, H2O, t-BuOH, rt, 2 h, 82%; (b) TFA, CH2Cl2, rt, 1 h, quant; (c) SUNBRIGHT® ME-050AS, ME-400AS, or PTE-400HS, DMF, rt, 3 h, 10, 46%, 11 82%, 12 92%, 14, 92%.