Skip to main content

View full-text article in PMC

. Author manuscript; available in PMC: 2015 Feb 13.

Published in final edited form as: ACS Med Chem Lett. 2013 Dec 20;5(2):133–137. doi: 10.1021/ml400370w

Table 1.

IC₅₀ values of Maraviroc derivatives in neutralization assay using HIV-1 pseudotype JR-FL

Compound	Compound-type	IC₅₀ (nM) ^a
1	Maraviroc	1.6 ± 0.25 ^b
2a	small molecule	360 ± 34 ^a
2b	small molecule	>1000 ^a
3	small molecule	0.96 ± 0.26 ^a
4	small molecule	27 ± 2.3 ^a
5	small molecule	2.6 ± 0.62 ^a
6	cpAbs	19 ± 2.6 ^a
7	cpAbs	7.7 ± 0.50 ^a
38C2	mAb carrier control	>1000 ^a
8	small molecule	3.0 ± 0.58 ^a
10	PEGylated compound	43 ± 9.6 ^a
11	PEGylated compound	49 ± 13 ^a
12	PEGylated compound	5.6 ± 2.0 ^c
14	PEGylated control	>1000 ^a

^a

Mean ± SE (N=3),

^b

Mean ± SE (N=12),

^c

Mean ± SE (N=5)