Table 1. Patient characteristics.

Shown are age (years), sex (F/M), treatment (Tx; IVMP, intravenous methylprednisolone; GA, glatiramer acetate); CSF volume obtained for this study, CSF white cell count (WBC), presence of OCB as determined by a clinical laboratory (+ if ≥ 2 CSF-restricted IgG bands); and numbers of IgG-VH sequences per patient contained in our IgG-VH reference database. Refer to Table S1 for additional clinical information. The CSF/PB VHref-CSF represents IgG-VH sequences that are restricted to the CSF or belong to bi-compartmental clusters of IgG-VH sequences; VHref-PB contains IgG-VH sequences from peripheral blood without a link to the CSF compartment (see Methods).

Patient ID	Age	Sex	CSF vol (ml)	WBC	OCB	VHref-CSF	VHref-PB
MS-1	29	F	8	1	+	294	135,346
MS-2	37	F	10	1	+	419	60,609
MS-3	39	F	10	ND	+	1,025	127,973
MS-4	39	F	10	3	+	61	78,136
MS-5	22	M	8	4	+	1,723	50,207