. Author manuscript; available in PMC: 2015 Jan 6.

Published in final edited form as: Environ Sci Technol. 2014 Jan 15;48(3):1964–1972. doi: 10.1021/es404568a

Table 1.

Identification of the aquatic vertebrate model(s) with the highest ligand-binding pocket similarity (denoted by X) compared to the corresponding human toxicity target (*indicates targets where other species should be investigated due to orthologs with only low or moderate pocket similarity).

Aquatic vertebrate model(s) with the highest ligand-binding pocket similarity
Receptor	D. rerio	P. promelas	T. rubripes	X. laevis	X. tropicalis
5-HT_2BR				X	X
A_2AR	X		X	X	X
M₂R	X		X		X
β₂AR	X	X	X	X
AR	X	X	X	X	X
MAO-A	X		X
CYP1A2	X		X
CYP2C9*			X	X
CYP2D6				X	X
CYP3A4	X	X
CRF₁R				X	X
D₃R	X		X
ERR1	X		X	X	X
ERα	X	X	X	X	X
ERβ	X	X	X	X	X
GCR	X	X	X	X	X
GIPR					X
H₁R	X		X		X
MCR	X		X	X
LXR	X		X	X	X
PXR*			X	X	X
CAR*				X	X
κOR	X		X		X
PDE4D	X		X		X
PPARγ					X
PR				X	X
TRα	X			X	X
TRβ	X	X	X	X	X