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. Author manuscript; available in PMC: 2008 Aug 5.
Published in final edited form as: J Biol Chem. 2008 May 5;283(26):17797–17804. doi: 10.1074/jbc.M800121200

Figure 4. Sequestration of membrane-bound tocopherol by αTTP mutants.

Figure 4

A) Location of AVED-affected residues relative to the ligand-binding pocket of αTTP. Plotted after Meier et al. (42; PDB accession 1OIP). B) Time-dependent changes in FRET between NBD-tocopherol and fluorescent liposomes in the presence of wild-type, R192H, E141K, H101Q, or R59W variants of αTTP (30 μM active protein). Conditions are as in Figure 1.