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Affinity of mutant αTTP proteins for NBD-tocopherol.
| TTP variant | Clinical phenotype | Kd (nM)a |
|---|---|---|
| Wild typeb | - | 8.5 ± 6.3 |
| Wild type | - | 9.8 ± 2.3 |
|
| ||
| R192Hb | AVED (mild) | 26.8 ± 7.7 |
| H101Qb | AVED (mild) | 38.9 ± 12.7 |
| A120Tb | AVED (mild) | 9.2 ± 5.4 |
|
| ||
| R59Wb | AVED (severe) | 70.8 ± 17.6 |
| E141Kb | AVED (severe) | 11.7 ± 2.7 |
| R221Wb | AVED (severe) | 21.7 ± 11.4 |
Averages and standard deviations from >3 titrations are shown.
Kd values were determined using GST fusion proteins; n = 3.
