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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: J Cell Mol Med. 2014 Mar 17;18(6):1104–1112. doi: 10.1111/jcmm.12255

Figure 3. miR-155 targets and FIZZ1 are upregulated in bone marrow derived macrophages (BMDMs) after polarization towards M2-phenotype.

Figure 3

(A) Quantitative analysis of specific markers for M1 polarization (iNOS, TNFα and MCP-1) and M2 polarization (Arg-1, YM1 and FIZZ1) in unpolarized BMDM (M0) and BMDMs polarized towards the M1 and M2 phenotypes. M2 macrophages derived from miR-155–/– mice show increased FIZZ1 expression. Graphs show fold change +/-SEM of representative results from 4 independent experiments, #P<0.1 with respect to WT group. (B) Quantitative analysis of validated miR-155 targets show no differences in unpolarized BMDM (M0) or BMDM polarized into an M1-phenotype. M2-phenotype shows upregulation of the validated miR-155 targets: BCL6, RhoA and SHIP1. Graphs show fold change +/- SEM of representative results from 4 independent experiments, *P<0.05 and #P<0.1 with respect to WT group.