Table 3.
The genotype distributions and allele frequencies of the LEPR gene Lys109Arg, Gln223Arg and Lys656Asn polymorphisms in an obese and non-obese population
| Genotype (frequency, %) | P-valuea | Allele (frequency, %) | P-valueb | ||||
|---|---|---|---|---|---|---|---|
|
Lys109Arg
| |||||||
| GG | AG | AA | G | A | |||
|
| |||||||
| Total | 0.875 | 0.893 | |||||
| Obese | 545 (67.0) | 243 (29.9) | 26 (3.2) | 1333 (81.9) | 295 (18.1) | ||
| Non-obese | 325 (66.2) | 152 (31.0) | 14 (2.9) | 802 (81.7) | 180 (18.3) | ||
| Case | 0.415 | 0.908 | |||||
| Obese | 395 (67.6) | 171 (29.3) | 18 (3.1) | 961 (82.3) | 207 (17.7) | ||
| Non-obese | 152 (65.8) | 75 (32.5) | 4 (1.7) | 379 (82.0) | 83 (82.0) | ||
| Control | 0.909 | 0.849 | |||||
| Obese | 150 (65.2) | 72 (31.3) | 8 (3.5) | 372 (80.9) | 88 (19.1) | ||
| Non-obese | 173 (66.5) | 77 (29.6) | 10 (3.8) | 423 (81.3) | 97 (18.7) | ||
|
| |||||||
|
Gln223Arg
| |||||||
| Total | 0.895 | 0.728 | |||||
| Obese | 608 (75.0) | 189 (23.3) | 14 (1.7) | 1405 (86.6) | 217 (13.4) | ||
| Non-obese | 360 (73.9) | 119 (24.4) | 8 (1.6) | 839 (86.1) | 135 (13.9) | ||
| Case | 0.583 | 0.943 | |||||
| Obese | 438 (75.4) | 136 (23.4) | 7 (1.2) | 1012 (87.1) | 150 (12.9) | ||
| Non-obese | 170 (74.9) | 56 (24.7) | 1 (0.4) | 396 (87.2) | 58 (12.8) | ||
| Control | 0.934 | 0.915 | |||||
| Obese | 170 (73.9) | 53 (23.0) | 7 (23.0) | 393 (85.4) | 67 (14.6) | ||
| Non-obese | 190(73.1) | 43 (85.2) | 7 (2.7) | 443 (85.2) | 77 (14.8) | ||
|
| |||||||
|
Lys656Asn
| |||||||
| GG | GC | CC | G | C | |||
|
| |||||||
| Total | 0.407 | 0.658 | |||||
| Obese | 693 (87.6) | 95 (12.0) | 3 (0.4) | 1481 (93.6) | 101 (6.4) | ||
| Non-obese | 415 (88.1) | 56 (11.9) | 0 | 886 (94.1) | 56 (5.9) | ||
| Case | 0.440 | 0.515 | |||||
| Obese | 497 (87.2) | 71 (12.5) | 2 (0.4) | 1065 (93.4) | 75 (6.6) | ||
| Non-obese | 187 (85.0) | 33 (15.0) | 0 | 407 (92.5) | 33 (7.5) | ||
| Control | 0.464 | 0.369 | |||||
| Obese | 196(88.7) | 24 (10.9) | 1 (0.5) | 416 (94.1) | 26 (5.9) | ||
| Non-obese | 228 (90.8) | 23 (4.6) | 0 | 479 (95.4) | 23 (4.6) | ||
a
P-value of the comparison of the additive genetic model using the generalized linear model.
b
P-value of the comparison of allelic frequencies.